Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F01%3A00003660" target="_blank" >RIV/00216208:11120/01:00003660 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer

Popis výsledku v původním jazyce

Background and Study Aims: The hereditary non-polyposis colorectal cancer (HNPCC) syndrome is caused by germline mutations in MMR genes and predisposed individuals to cancers of the colon and other specific sites. We assessed the prevalence of HNPCC in Czech patient with endoscopic diagnosis of colorectal cancer. Patient and Methods: We examined 2,464 patients by total colonoscopy. Patient with CRC suspected of HNPCC we screened for germline mutations of mismatch repair genes hMLH1 and hMLH2. Results: Out of a total of 2,464 patients examined 128 were found to have CRC. We found germline mutation in hMLH1 gene in two patients (1.5%). Conclusions: The occurrence of hereditary cancer in Czech patients is lower than suspected, probably in accordance witha high share of sporadic colorectal cancer.

Název v anglickém jazyce

Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer

Popis výsledku anglicky

Background and Study Aims: The hereditary non-polyposis colorectal cancer (HNPCC) syndrome is caused by germline mutations in MMR genes and predisposed individuals to cancers of the colon and other specific sites. We assessed the prevalence of HNPCC in Czech patient with endoscopic diagnosis of colorectal cancer. Patient and Methods: We examined 2,464 patients by total colonoscopy. Patient with CRC suspected of HNPCC we screened for germline mutations of mismatch repair genes hMLH1 and hMLH2. Results: Out of a total of 2,464 patients examined 128 were found to have CRC. We found germline mutation in hMLH1 gene in two patients (1.5%). Conclusions: The occurrence of hereditary cancer in Czech patients is lower than suspected, probably in accordance witha high share of sporadic colorectal cancer.

Druh

D - Stať ve sborníku

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

8th Biennial Congress of the European Council of Coloproctology (ECCP)

ISBN

88-323-1429-0

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

219-224

Název nakladatele

Medimond

Místo vydání

Bologna

Místo konání akce

Praha

Datum konání akce

1. 1. 2001

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000172544200034