Positive contrast visualization of SPIO-labeled pancreatic islets using echo-dephased steady-state free precession

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A6943" target="_blank" >RIV/00216208:11130/11:6943 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/11:00002433

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pubmed/20683599" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/20683599</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Positive contrast visualization of SPIO-labeled pancreatic islets using echo-dephased steady-state free precession

Popis výsledku v původním jazyce

Objective MRI has recently been introduced as a promising method of monitoring the transplanted pancreatic islets labelled with superparamagnetic iron oxide (SPIO). However, the traditional T-2*-weighted approach frequently yields ambiguous results because of the negative contrast of the SPIO particles on the background of other body components. This obstacle could be overcome with the use of a novel method known as echo-dephased steady state free precession (SSFP), generating positive contrast in the presence of paramagnetic material. Methods In phantoms, we achieved exact localisation and clear positive contrast visualisation of human SPIO labelled islets. Using the proposed method we demonstrated the ability to detect even a single pancreatic isletagainst a homogeneous background. Results In vivo experiments in rats confirmed reliable and accurate localisation of transplanted SPIO labelled islets. Conclusion The echo-dephased SSFP technique could successfully visualise SPIO-labelle

Název v anglickém jazyce

Positive contrast visualization of SPIO-labeled pancreatic islets using echo-dephased steady-state free precession

Popis výsledku anglicky

Objective MRI has recently been introduced as a promising method of monitoring the transplanted pancreatic islets labelled with superparamagnetic iron oxide (SPIO). However, the traditional T-2*-weighted approach frequently yields ambiguous results because of the negative contrast of the SPIO particles on the background of other body components. This obstacle could be overcome with the use of a novel method known as echo-dephased steady state free precession (SSFP), generating positive contrast in the presence of paramagnetic material. Methods In phantoms, we achieved exact localisation and clear positive contrast visualisation of human SPIO labelled islets. Using the proposed method we demonstrated the ability to detect even a single pancreatic isletagainst a homogeneous background. Results In vivo experiments in rats confirmed reliable and accurate localisation of transplanted SPIO labelled islets. Conclusion The echo-dephased SSFP technique could successfully visualise SPIO-labelle

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Radiology

ISSN

0938-7994

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

214-220

Kód UT WoS článku

000284899700029

EID výsledku v databázi Scopus

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