Healthy Lung Tissue Response to Mechanical Ventilation in an Experimental Porcine Model
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10272134" target="_blank" >RIV/00216208:11140/14:10272134 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Healthy Lung Tissue Response to Mechanical Ventilation in an Experimental Porcine Model
Popis výsledku v původním jazyce
Background: The aim of this comparative study was to assess the impact of two different settings of tidal volume (Vt) on the function and morphology of the mechanically ventilated lungs during a 12-hour period. Materials and Methods: A total of 32 animals were randomly divided into two groups. Group A included piglets ventilated with a Vt of 6 ml/kg and group B piglets ventilated with a Vt of 10 ml/kg. Lung functions and pulmonary mechanics were evaluated after 1 and 12 hours of mechanical ventilation.Morphological changes of the lung tissue were evaluated at the end of the study. Result: Twelve hours of lower Vt ventilation was associated with the development of respiratory acidosis but minimal histological changes. Higher Vt led to pronounced histological changes in terms of proliferation and apoptosis and a decrease of dynamic compliance, with trend towards lower oxygenation during the study. Conclusion: Mechanical ventilation with a Vt of 6 ml/kg induces minimal histological lung
Název v anglickém jazyce
Healthy Lung Tissue Response to Mechanical Ventilation in an Experimental Porcine Model
Popis výsledku anglicky
Background: The aim of this comparative study was to assess the impact of two different settings of tidal volume (Vt) on the function and morphology of the mechanically ventilated lungs during a 12-hour period. Materials and Methods: A total of 32 animals were randomly divided into two groups. Group A included piglets ventilated with a Vt of 6 ml/kg and group B piglets ventilated with a Vt of 10 ml/kg. Lung functions and pulmonary mechanics were evaluated after 1 and 12 hours of mechanical ventilation.Morphological changes of the lung tissue were evaluated at the end of the study. Result: Twelve hours of lower Vt ventilation was associated with the development of respiratory acidosis but minimal histological changes. Higher Vt led to pronounced histological changes in terms of proliferation and apoptosis and a decrease of dynamic compliance, with trend towards lower oxygenation during the study. Conclusion: Mechanical ventilation with a Vt of 6 ml/kg induces minimal histological lung
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FG - Pediatrie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedicínské centrum Lékařské fakulty v Plzni</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
In Vivo
ISSN
0258-851X
e-ISSN
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Svazek periodika
28
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
GR - Řecká republika
Počet stran výsledku
7
Strana od-do
803-809
Kód UT WoS článku
000341281900016
EID výsledku v databázi Scopus
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