Ara h 1 but not Ara h 2 strongly adheres to oral epithelium and remains in the oral area upon peanut release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F23%3A10464659" target="_blank" >RIV/00216208:11150/23:10464659 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=W3eg2MXWPV" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=W3eg2MXWPV</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/all.15677" target="_blank" >10.1111/all.15677</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ara h 1 but not Ara h 2 strongly adheres to oral epithelium and remains in the oral area upon peanut release

Popis výsledku v původním jazyce

The release of peanut allergens from their natural source by human mastication, their persistence, and interaction with oral epithelial cells as a previous step of allergic sensitization were analyzed in healthy individuals and in the DOK cell line. The persistence of Ara h 1, Ara h 2, and Ara h 3 in saliva, oral areas, and their interaction with epithelial cells from the dorsal tongue was analyzed by specific immunoassay. Ara h 1, as opposed to Ara h 2, showed specific adherence properties to keratinocytes from the tongue in a dose-dependent manner. The results demonstrate for the first time that Ara h 1 but not Ara h 2 attaches to oral epithelial cells after peanut consumption with a continuous presence of Ara h 1 in the oral area, even after regular cleansing.

Název v anglickém jazyce

Ara h 1 but not Ara h 2 strongly adheres to oral epithelium and remains in the oral area upon peanut release

Popis výsledku anglicky

The release of peanut allergens from their natural source by human mastication, their persistence, and interaction with oral epithelial cells as a previous step of allergic sensitization were analyzed in healthy individuals and in the DOK cell line. The persistence of Ara h 1, Ara h 2, and Ara h 3 in saliva, oral areas, and their interaction with epithelial cells from the dorsal tongue was analyzed by specific immunoassay. Ara h 1, as opposed to Ara h 2, showed specific adherence properties to keratinocytes from the tongue in a dose-dependent manner. The results demonstrate for the first time that Ara h 1 but not Ara h 2 attaches to oral epithelial cells after peanut consumption with a continuous presence of Ara h 1 in the oral area, even after regular cleansing.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Allergy

ISSN

0105-4538

e-ISSN

1398-9995

Svazek periodika

78

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

2024-2028

Kód UT WoS článku

000943886100001

EID výsledku v databázi Scopus

2-s2.0-85149589128