Medicinal Application of Carboranes Inhibition of HIV Protease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10099103" target="_blank" >RIV/00216208:11310/12:10099103 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388980:_____/12:00376636 RIV/61388963:_____/12:00376636

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Medicinal Application of Carboranes Inhibition of HIV Protease

Popis výsledku v původním jazyce

The aspartic protease of the human immunodeficiency virus is one of the most extensively studied enzymes known to man. More than 200 X-ray structures of the protein in the presence or absence of ligands or inhibitors have been determined to date, and thesymmetric depictions of this dimeric enzyme have become one of the icons of modern structural biology. The HIV protease is crucial for the production of infectious viral particles, and PR inhibitors are potent and specific anti HIV drugs. The successfulrational design of HIV PIs is one of the most striking examples of structure-based drug design. In this chapter, we will explain why the design of novel, potent PIs is still urgently needed and that derivatives of bis(dicarbollide)(1-) ion [(1,2-C2B9H11)-3,3'-Co(III)](1-), a compound well known to the carborane community, act as unexpected class of specific HIV PIs. We shall review their activity, specificity, mechanism of action, and binding mode to HIV protease

Název v anglickém jazyce

Medicinal Application of Carboranes Inhibition of HIV Protease

Popis výsledku anglicky

The aspartic protease of the human immunodeficiency virus is one of the most extensively studied enzymes known to man. More than 200 X-ray structures of the protein in the presence or absence of ligands or inhibitors have been determined to date, and thesymmetric depictions of this dimeric enzyme have become one of the icons of modern structural biology. The HIV protease is crucial for the production of infectious viral particles, and PR inhibitors are potent and specific anti HIV drugs. The successfulrational design of HIV PIs is one of the most striking examples of structure-based drug design. In this chapter, we will explain why the design of novel, potent PIs is still urgently needed and that derivatives of bis(dicarbollide)(1-) ion [(1,2-C2B9H11)-3,3'-Co(III)](1-), a compound well known to the carborane community, act as unexpected class of specific HIV PIs. We shall review their activity, specificity, mechanism of action, and binding mode to HIV protease

Druh

C - Kapitola v odborné knize

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Boron Science - New Technologies and Applications

ISBN

978-1-4398-2662-1

Počet stran výsledku

30

Strana od-do

41-70

Počet stran knihy

850

Název nakladatele

CRC Press Taylor & Francis Group

Místo vydání

Boca Raton

Kód UT WoS kapitoly

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