Formation and disruption of tonotopy in a large-scale model of the auditory cortex

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F15%3A10313779" target="_blank" >RIV/00216208:11320/15:10313779 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/15:00452407

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10827-015-0568-2" target="_blank" >http://dx.doi.org/10.1007/s10827-015-0568-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10827-015-0568-2" target="_blank" >10.1007/s10827-015-0568-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Formation and disruption of tonotopy in a large-scale model of the auditory cortex

Popis výsledku v původním jazyce

There is ample experimental evidence describing changes of tonotopic organisation in the auditory cortex due to environmental factors. In order to uncover the underlying mechanisms, we designed a large-scale computational model of the auditory cortex. The model has up to 100 000 Izhikevich's spiking neurons of 17 different types, almost 21 million synapses, which are evolved according to Spike-Timing-Dependent Plasticity (STDP) and have an architecture akin to existing observations. Validation of the model revealed alternating synchronised/desynchronised states and different modes of oscillatory activity. We provide insight into these phenomena via analysing the activity of neuronal subtypes and testing different causal interventions into the simulation. Our model is able to produce experimental predictions on a cell type basis. To study the influence of environmental factors on the tonotopy, different types of auditory stimulations during the evolution of the network were modelled and

Název v anglickém jazyce

Formation and disruption of tonotopy in a large-scale model of the auditory cortex

Popis výsledku anglicky

There is ample experimental evidence describing changes of tonotopic organisation in the auditory cortex due to environmental factors. In order to uncover the underlying mechanisms, we designed a large-scale computational model of the auditory cortex. The model has up to 100 000 Izhikevich's spiking neurons of 17 different types, almost 21 million synapses, which are evolved according to Spike-Timing-Dependent Plasticity (STDP) and have an architecture akin to existing observations. Validation of the model revealed alternating synchronised/desynchronised states and different modes of oscillatory activity. We provide insight into these phenomena via analysing the activity of neuronal subtypes and testing different causal interventions into the simulation. Our model is able to produce experimental predictions on a cell type basis. To study the influence of environmental factors on the tonotopy, different types of auditory stimulations during the evolution of the network were modelled and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP303%2F12%2F1347" target="_blank" >GAP303/12/1347: Mechanizmy zpracování komplexních zvuků v neuronových okruzích sluchového systému</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Computational Neuroscience

ISSN

0929-5313

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

23

Strana od-do

131-153

Kód UT WoS článku

000361467700003

EID výsledku v databázi Scopus

2-s2.0-84941935633