CHANGES OF BLOOD PRESSURE BAROREFLEX REGULATION IN YOUNG TYPE-1 DIABETICS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00054383" target="_blank" >RIV/00216224:14110/11:00054383 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

CHANGES OF BLOOD PRESSURE BAROREFLEX REGULATION IN YOUNG TYPE-1 DIABETICS

Popis výsledku v původním jazyce

Our aim was to study the relationship between f and BRS during spontaneous variations and to evaluate the f and BRS relationship as a diagnostic test of autonomous nervous impairment in young T1DM. We monitored 14 T1DM (age 20-25 years, DM duration 10-15years, the Michigan Neuropathy Screening Instrument did not reveal neuropathy in any patients) and 14 age-matched controls (Co). Blood pressure and heart rate were recorded beat-to-beat by Finapres for 40 minutes in supine position. BRS was determined by the spectral method, peak f of the cross spectra SBP x PI was determined in a 0.06 ? 0.12 Hz range. Receiver operation curves (ROC) were calculated for f, BRS, and F(z). F(z) values were calculated from equations F(z)=1/(1+ exp(-z)), z=a+b1*BRS+b2*f. The ROC of f and the ROC of F(z)-values revealed 50% sensitivity with 100% specificity. The results indicate that the measurement of f and BRS can reveal subtle impairment of the autonomic nervous system where standard tests failed.

Název v anglickém jazyce

CHANGES OF BLOOD PRESSURE BAROREFLEX REGULATION IN YOUNG TYPE-1 DIABETICS

Popis výsledku anglicky

Our aim was to study the relationship between f and BRS during spontaneous variations and to evaluate the f and BRS relationship as a diagnostic test of autonomous nervous impairment in young T1DM. We monitored 14 T1DM (age 20-25 years, DM duration 10-15years, the Michigan Neuropathy Screening Instrument did not reveal neuropathy in any patients) and 14 age-matched controls (Co). Blood pressure and heart rate were recorded beat-to-beat by Finapres for 40 minutes in supine position. BRS was determined by the spectral method, peak f of the cross spectra SBP x PI was determined in a 0.06 ? 0.12 Hz range. Receiver operation curves (ROC) were calculated for f, BRS, and F(z). F(z) values were calculated from equations F(z)=1/(1+ exp(-z)), z=a+b1*BRS+b2*f. The ROC of f and the ROC of F(z)-values revealed 50% sensitivity with 100% specificity. The results indicate that the measurement of f and BRS can reveal subtle impairment of the autonomic nervous system where standard tests failed.

Druh

O - Ostatní výsledky

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů