Cell motility in marine early emerging apicomplexans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00058218" target="_blank" >RIV/00216224:14310/12:00058218 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/14:00101823

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Cell motility in marine early emerging apicomplexans

Popis výsledku v původním jazyce

Apicomplexans represent one of the most successful and diverse group of unicellular parasites exhibiting unique adaptations to their life style. Many of them are causative agents for major human diseases (such as malaria, toxoplasmosis and cryptosporidiosis), which are still poorly controlled and require development of novel sustainable therapies. The apicomplexan cytoskeletal elements play an important role in various life processes and thus they represent a potential target for chemotherapeutic intervention. Their highly motile invasive zoites use a unique conserved form of actin-based gliding motility for movement, host cell invasion and tissue traversal. Our intent is to investigate if the glideosome concept, proposed in Toxoplasma, could be also applied to basal lineages of Apicomplexa. We focus on deep-branching groups, especially gregarines and protococcidians, restricted to invertebrates (Diakin et al. 2012).

Název v anglickém jazyce

Cell motility in marine early emerging apicomplexans

Popis výsledku anglicky

Apicomplexans represent one of the most successful and diverse group of unicellular parasites exhibiting unique adaptations to their life style. Many of them are causative agents for major human diseases (such as malaria, toxoplasmosis and cryptosporidiosis), which are still poorly controlled and require development of novel sustainable therapies. The apicomplexan cytoskeletal elements play an important role in various life processes and thus they represent a potential target for chemotherapeutic intervention. Their highly motile invasive zoites use a unique conserved form of actin-based gliding motility for movement, host cell invasion and tissue traversal. Our intent is to investigate if the glideosome concept, proposed in Toxoplasma, could be also applied to basal lineages of Apicomplexa. We focus on deep-branching groups, especially gregarines and protococcidians, restricted to invertebrates (Diakin et al. 2012).

Druh

O - Ostatní výsledky

CEP obor

EG - Zoologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GBP505%2F12%2FG112" target="_blank" >GBP505/12/G112: ECIP - Evropské centrum ichtyoparazitologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů