New one-pot methods for preparation of cyclohexanecarbonitrile ? Green Chemistry metrics evaluation for one-pot and similar multi-step syntheses
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074529" target="_blank" >RIV/00216224:14310/14:00074529 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.4236/gsc.2014.42011" target="_blank" >http://dx.doi.org/10.4236/gsc.2014.42011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4236/gsc.2014.42011" target="_blank" >10.4236/gsc.2014.42011</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
New one-pot methods for preparation of cyclohexanecarbonitrile ? Green Chemistry metrics evaluation for one-pot and similar multi-step syntheses
Popis výsledku v původním jazyce
Three new multi-step one-pot processes for high-yielding cyclohexanecarbonitrile synthesis starting from cyclohexanone were developed for industrial application. In contrast to the current synthetic process all of the processes described were designed toproceed completely in methanol as a uniform solvent and the key oxidation step can be realized either as stoichiometric or catalytic. Atom efficiency of processes is rel-atively advanced with high regioselectivity, reaction by-products are either from environmental pool ? carbon dioxide and nitrogen or they can be reused ? sodium chloride. Solvent ? methanol and other aux-iliaries ? cyclohexane, copper catalyst can be reused after recycling as well. EcoScale for all three designed processes was evaluated and compared with current synthesis described in the past. Green chemistry metrics, including newly introduced evaluative tool ? Sustainability Index of the Synthesis (SIS), were applied to evaluate design of described one-pot synthese
Název v anglickém jazyce
New one-pot methods for preparation of cyclohexanecarbonitrile ? Green Chemistry metrics evaluation for one-pot and similar multi-step syntheses
Popis výsledku anglicky
Three new multi-step one-pot processes for high-yielding cyclohexanecarbonitrile synthesis starting from cyclohexanone were developed for industrial application. In contrast to the current synthetic process all of the processes described were designed toproceed completely in methanol as a uniform solvent and the key oxidation step can be realized either as stoichiometric or catalytic. Atom efficiency of processes is rel-atively advanced with high regioselectivity, reaction by-products are either from environmental pool ? carbon dioxide and nitrogen or they can be reused ? sodium chloride. Solvent ? methanol and other aux-iliaries ? cyclohexane, copper catalyst can be reused after recycling as well. EcoScale for all three designed processes was evaluated and compared with current synthesis described in the past. Green chemistry metrics, including newly introduced evaluative tool ? Sustainability Index of the Synthesis (SIS), were applied to evaluate design of described one-pot synthese
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CC - Organická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/2A-1TP1%2F090" target="_blank" >2A-1TP1/090: Nové katalyzátory a činidla pro udržitelné zelené syntézy a kombinatoriální syntézy.</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Green and Sustainable Chemistry
ISSN
2160-6951
e-ISSN
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Svazek periodika
2014
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
70-79
Kód UT WoS článku
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EID výsledku v databázi Scopus
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