Microbiome and pharmacotherapy in patients with gastrointestinal disorders

Kód výsledku v IS VaVaI

RIV/00216224:14310/23:00134642 - isvavai.cz

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Microbiome and pharmacotherapy in patients with gastrointestinal disorders

Popis výsledku v původním jazyce

Background: Etiopathogenesis of gastrointestinal disorders (GDs), such as gastroesophageal reflux disease (GERD) and its complications, pancreatic cancer (PANC), and colorectal adenocarcinoma (CRC) is multifactorial; risk factors for disease development and/or progression include external factors, dysbiosis of host microbiota, genetic predisposition, and responsiveness to therapy. Objectives: The main aim of the dissertation project is to identify potential markers at the level of the host microbiome. Methods: Human and microbial DNA will be isolated from blood and biopsies from the digestive tract. Microbial DNA will be analyzed by 16S rRNA amplicon sequencing and quantified by multiplex qPCR method. Outcomes: Paired comparison of bacteriomes between healthy and pathological parts of the digestive tract will be performed to identify potentially risky host bacteriome profiles.

Název v anglickém jazyce

Microbiome and pharmacotherapy in patients with gastrointestinal disorders

Popis výsledku anglicky

Background: Etiopathogenesis of gastrointestinal disorders (GDs), such as gastroesophageal reflux disease (GERD) and its complications, pancreatic cancer (PANC), and colorectal adenocarcinoma (CRC) is multifactorial; risk factors for disease development and/or progression include external factors, dysbiosis of host microbiota, genetic predisposition, and responsiveness to therapy. Objectives: The main aim of the dissertation project is to identify potential markers at the level of the host microbiome. Methods: Human and microbial DNA will be isolated from blood and biopsies from the digestive tract. Microbial DNA will be analyzed by 16S rRNA amplicon sequencing and quantified by multiplex qPCR method. Outcomes: Paired comparison of bacteriomes between healthy and pathological parts of the digestive tract will be performed to identify potentially risky host bacteriome profiles.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30101 - Human genetics

Projekt

NU20-03-00126: Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů