Microbiome and pharmacotherapy in patients with gastrointestinal disorders
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00134642" target="_blank" >RIV/00216224:14310/23:00134642 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Microbiome and pharmacotherapy in patients with gastrointestinal disorders
Popis výsledku v původním jazyce
Background: Etiopathogenesis of gastrointestinal disorders (GDs), such as gastroesophageal reflux disease (GERD) and its complications, pancreatic cancer (PANC), and colorectal adenocarcinoma (CRC) is multifactorial; risk factors for disease development and/or progression include external factors, dysbiosis of host microbiota, genetic predisposition, and responsiveness to therapy. Objectives: The main aim of the dissertation project is to identify potential markers at the level of the host microbiome. Methods: Human and microbial DNA will be isolated from blood and biopsies from the digestive tract. Microbial DNA will be analyzed by 16S rRNA amplicon sequencing and quantified by multiplex qPCR method. Outcomes: Paired comparison of bacteriomes between healthy and pathological parts of the digestive tract will be performed to identify potentially risky host bacteriome profiles.
Název v anglickém jazyce
Microbiome and pharmacotherapy in patients with gastrointestinal disorders
Popis výsledku anglicky
Background: Etiopathogenesis of gastrointestinal disorders (GDs), such as gastroesophageal reflux disease (GERD) and its complications, pancreatic cancer (PANC), and colorectal adenocarcinoma (CRC) is multifactorial; risk factors for disease development and/or progression include external factors, dysbiosis of host microbiota, genetic predisposition, and responsiveness to therapy. Objectives: The main aim of the dissertation project is to identify potential markers at the level of the host microbiome. Methods: Human and microbial DNA will be isolated from blood and biopsies from the digestive tract. Microbial DNA will be analyzed by 16S rRNA amplicon sequencing and quantified by multiplex qPCR method. Outcomes: Paired comparison of bacteriomes between healthy and pathological parts of the digestive tract will be performed to identify potentially risky host bacteriome profiles.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30101 - Human genetics
Návaznosti výsledku
Projekt
<a href="/cs/project/NU20-03-00126" target="_blank" >NU20-03-00126: Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů