Acquired haemophilia as a complicating factor in treatment of non-muscle invasive bladder cancer: A case report

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110361" target="_blank" >RIV/00843989:_____/23:E0110361 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/23:A2402N2L

Výsledek na webu

<a href="https://www.wjgnet.com/2307-8960/full/v11/i22/5338.htm" target="_blank" >https://www.wjgnet.com/2307-8960/full/v11/i22/5338.htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12998/wjcc.v11.i22.5338" target="_blank" >10.12998/wjcc.v11.i22.5338</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acquired haemophilia as a complicating factor in treatment of non-muscle invasive bladder cancer: A case report

Popis výsledku v původním jazyce

Background: Acquired haemophilia (AH) is a serious autoimmune haematological disease caused by the production of auto-antibodies against coagulation factor VIII. In some patients, AH is associated with a concomitant malignancy. In case of surgical intervention, AH poses a high risk of life-threatening bleeding. Case summary: A 60-year-old female patient with multiple recurrences of non-muscle invasive bladder cancer underwent transurethral tumour resection. A severe haematuria developed postoperatively warranting two endoscopic revisions; however, no clear source of bleeding was identified in the bladder. Subsequent haematological examination established a diagnosis of AH. Treatment with factor VIII inhibitor bypass activity and immunosuppressive therapy was initiated immediately. The patient responded well to the therapy and was discharged from the hospital 21 d after the primary surgery. At the 38-mo follow-up, both AH and bladder cancer remained in complete remission. Conclusion: AH is a rare, life-threatening haematological disease. AH should be considered in patients with persistent severe haematuria or other bleeding symptoms, especially if combined with isolated activated partial thromboplastin time prolongation.

Název v anglickém jazyce

Acquired haemophilia as a complicating factor in treatment of non-muscle invasive bladder cancer: A case report

Popis výsledku anglicky

Background: Acquired haemophilia (AH) is a serious autoimmune haematological disease caused by the production of auto-antibodies against coagulation factor VIII. In some patients, AH is associated with a concomitant malignancy. In case of surgical intervention, AH poses a high risk of life-threatening bleeding. Case summary: A 60-year-old female patient with multiple recurrences of non-muscle invasive bladder cancer underwent transurethral tumour resection. A severe haematuria developed postoperatively warranting two endoscopic revisions; however, no clear source of bleeding was identified in the bladder. Subsequent haematological examination established a diagnosis of AH. Treatment with factor VIII inhibitor bypass activity and immunosuppressive therapy was initiated immediately. The patient responded well to the therapy and was discharged from the hospital 21 d after the primary surgery. At the 38-mo follow-up, both AH and bladder cancer remained in complete remission. Conclusion: AH is a rare, life-threatening haematological disease. AH should be considered in patients with persistent severe haematuria or other bleeding symptoms, especially if combined with isolated activated partial thromboplastin time prolongation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30217 - Urology and nephrology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

World journal of clinical cases

ISSN

2307-8960

e-ISSN

2307-8960

Svazek periodika

11

Číslo periodika v rámci svazku

22

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

5338-5343

Kód UT WoS článku

001054213900016

EID výsledku v databázi Scopus

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