Primary Evaluation of Pcl/pei Nanofibres in Terms of the Surface Functionality for Biomolecules Attachment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F18%3A00007700" target="_blank" >RIV/46747885:24620/18:00007700 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.confer.cz/nanocon/2017/read/359-functional-nanofibres-for-biomedical-application-and-biomolecules-attachment.pdf" target="_blank" >https://www.confer.cz/nanocon/2017/read/359-functional-nanofibres-for-biomedical-application-and-biomolecules-attachment.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Primary Evaluation of Pcl/pei Nanofibres in Terms of the Surface Functionality for Biomolecules Attachment

Popis výsledku v původním jazyce

Paper in conference proseeding with abstract: Nanofibrous matrices represent an attractive material for biomedical applications - mainly due to their high specific surface and small pore size, which make them interesting material for drug delivery matrixes construction. Besides the morphological characteristics, the surface functionality strongly affects the drug-matrix interaction, drug conjugation and drug release kinetics. Implication of primary amino (-NH2) groups to the surface of nanofibres can improve their performance and enable conjugation of drug via covalent binding and/or electrostatic interactions. The aim of this study was to evaluate applicability a nanofibrous material based on blend of two biocompatible and biodegradable polymers -poly-epsilon-caprolactone (PCL) and polyethylenimine (PEI) produced by needleless electrospinning. The electrospun matrices were evaluated in terms of morphology, functional groups availability and short term stability. Moreover, biocompatibility to the 3T3 fibroblastic cell line was verified in direct contact. Binding capacity estimation was performed on a model molecule (BSA) in order to demonstrate binding capacity of the system and its applicability for protein immobilization for wound management.

Název v anglickém jazyce

Primary Evaluation of Pcl/pei Nanofibres in Terms of the Surface Functionality for Biomolecules Attachment

Popis výsledku anglicky

Paper in conference proseeding with abstract: Nanofibrous matrices represent an attractive material for biomedical applications - mainly due to their high specific surface and small pore size, which make them interesting material for drug delivery matrixes construction. Besides the morphological characteristics, the surface functionality strongly affects the drug-matrix interaction, drug conjugation and drug release kinetics. Implication of primary amino (-NH2) groups to the surface of nanofibres can improve their performance and enable conjugation of drug via covalent binding and/or electrostatic interactions. The aim of this study was to evaluate applicability a nanofibrous material based on blend of two biocompatible and biodegradable polymers -poly-epsilon-caprolactone (PCL) and polyethylenimine (PEI) produced by needleless electrospinning. The electrospun matrices were evaluated in terms of morphology, functional groups availability and short term stability. Moreover, biocompatibility to the 3T3 fibroblastic cell line was verified in direct contact. Binding capacity estimation was performed on a model molecule (BSA) in order to demonstrate binding capacity of the system and its applicability for protein immobilization for wound management.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

9th International Conference on Nanomaterials - Research and Application (NANOCON 2017)

ISBN

978-80-87294-81-9

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

605-610

Název nakladatele

Tanger

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

1. 1. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000452823300100