Cyanobacterial sigma factors: Current and future applications for biotechnological advances

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901141" target="_blank" >RIV/60076658:12310/20:43901141 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/20:00525149

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0734975020300148?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0734975020300148?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotechadv.2020.107517" target="_blank" >10.1016/j.biotechadv.2020.107517</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cyanobacterial sigma factors: Current and future applications for biotechnological advances

Popis výsledku v původním jazyce

A sigma (sigma) factor is a constituent of bacterial RNA polymerase that guides the holoenzyme to promoter sequences and initiates transcription. In addition to a primary housekeeping sigma factor, bacteria contain a number of alternative sigma factors which recognize a specific set of promoters. By replacing the primary sigma factor with alternative variants, the cell controls transcription of the whole sets of genes, typically to acclimate to changes in the environment. As key regulatory elements, sigma factors are frequent targets of genetic manipulation aimed at the improvement of bacterial stress tolerance and capacity for bioproduction. Cyanobacteria are a phylum of bacteria capable of oxygenic photosynthesis and there is a great interest to employ them as biochemical and biofuel production hosts. Engineering of sigma factor genes has become an important strategy to improve robustness and suitability of cyanobacteria for the production of high-value metabolites such as polyhydroxybutyrate, succinate, sucrose or hydrogen. Here, we summarize the current knowledge about the regulatory role of different sigma factor classes in cyanobacteria, highlighting their biotechnological potential.

Název v anglickém jazyce

Cyanobacterial sigma factors: Current and future applications for biotechnological advances

Popis výsledku anglicky

A sigma (sigma) factor is a constituent of bacterial RNA polymerase that guides the holoenzyme to promoter sequences and initiates transcription. In addition to a primary housekeeping sigma factor, bacteria contain a number of alternative sigma factors which recognize a specific set of promoters. By replacing the primary sigma factor with alternative variants, the cell controls transcription of the whole sets of genes, typically to acclimate to changes in the environment. As key regulatory elements, sigma factors are frequent targets of genetic manipulation aimed at the improvement of bacterial stress tolerance and capacity for bioproduction. Cyanobacteria are a phylum of bacteria capable of oxygenic photosynthesis and there is a great interest to employ them as biochemical and biofuel production hosts. Engineering of sigma factor genes has become an important strategy to improve robustness and suitability of cyanobacteria for the production of high-value metabolites such as polyhydroxybutyrate, succinate, sucrose or hydrogen. Here, we summarize the current knowledge about the regulatory role of different sigma factor classes in cyanobacteria, highlighting their biotechnological potential.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/LO1416" target="_blank" >LO1416: Algatech plus</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biotechnology Advances

ISSN

0734-9750

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

MAY-JUN 2020

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

000522635400007

EID výsledku v databázi Scopus

2-s2.0-85078418245