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Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F20%3A43900908" target="_blank" >RIV/60076658:12520/20:43900908 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://doi.org/10.1016/j.ygeno.2020.03.018" target="_blank" >https://doi.org/10.1016/j.ygeno.2020.03.018</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ygeno.2020.03.018" target="_blank" >10.1016/j.ygeno.2020.03.018</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle

  • Popis výsledku v původním jazyce

    Myogenic factor 5 plays actively roles in the regulation of myogenesis. The aims of this study are to identify the evolution information of MYF5 protein among 10 domestic and mammalian animals, to uncover the expression patterns of MYF5 gene in calves and adults of Qinchuan cattle, and to expose the genetic variants of the MYF5 gene and explore its effect on cattle growth traits and beef quality traits in Qinchuan cattle. The bioinformatics results showed that the MYF5 proteins highly conserved in different mammalian or domestic animals apart from chicken. The expression level of MYF5 gene in the heart, muscle, lung, large intestine and liver was greater than that of other tissues. PCR amplicons sequencing identified four novel SNPs at g.5738A &gt; G, g.5785C &gt; T and g.5816A &gt; G in the 3rd exon region and g.6535A &gt; G in the 3&apos; UTR. Genotypic frequencies of g.5785C &gt; T was harshly deviated from the HWE (P &lt; .05). Genetic diversity was low or intermediate for the four SNPs and those SNPs were in the weak linkage disequilibrium. Association analysis results indicated g.5785C &gt; T, g.5816A &gt; G and g.6535A &gt; G significant effect on growth performance and beef quality traits of Qinchuan cattle. H1H3 diplotype had greater body size and better beef quality. All the results implicate that the MYF5 gene might be applied as a promising candidate gene in Qinchuan cattle breeding.

  • Název v anglickém jazyce

    Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle

  • Popis výsledku anglicky

    Myogenic factor 5 plays actively roles in the regulation of myogenesis. The aims of this study are to identify the evolution information of MYF5 protein among 10 domestic and mammalian animals, to uncover the expression patterns of MYF5 gene in calves and adults of Qinchuan cattle, and to expose the genetic variants of the MYF5 gene and explore its effect on cattle growth traits and beef quality traits in Qinchuan cattle. The bioinformatics results showed that the MYF5 proteins highly conserved in different mammalian or domestic animals apart from chicken. The expression level of MYF5 gene in the heart, muscle, lung, large intestine and liver was greater than that of other tissues. PCR amplicons sequencing identified four novel SNPs at g.5738A &gt; G, g.5785C &gt; T and g.5816A &gt; G in the 3rd exon region and g.6535A &gt; G in the 3&apos; UTR. Genotypic frequencies of g.5785C &gt; T was harshly deviated from the HWE (P &lt; .05). Genetic diversity was low or intermediate for the four SNPs and those SNPs were in the weak linkage disequilibrium. Association analysis results indicated g.5785C &gt; T, g.5816A &gt; G and g.6535A &gt; G significant effect on growth performance and beef quality traits of Qinchuan cattle. H1H3 diplotype had greater body size and better beef quality. All the results implicate that the MYF5 gene might be applied as a promising candidate gene in Qinchuan cattle breeding.

Klasifikace

  • Druh

    J<sub>ost</sub> - Ostatní články v recenzovaných periodicích

  • CEP obor

  • OECD FORD obor

    40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming

Návaznosti výsledku

  • Projekt

  • Návaznosti

    S - Specificky vyzkum na vysokych skolach

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    GENOMICS

  • ISSN

    0888-7543

  • e-ISSN

  • Svazek periodika

    112

  • Číslo periodika v rámci svazku

    4

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    9

  • Strana od-do

    2804-2812

  • Kód UT WoS článku

    000534479700015

  • EID výsledku v databázi Scopus

    2-s2.0-85082526743