Karvakrol jako inhibitor cyklooxygenazy-1 a -2 klíčových enzymů biosyntézy prostaglandínů: in vitro test

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41610%2F06%3A17515" target="_blank" >RIV/60460709:41610/06:17515 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Carvacrol as the inhibitor of cyclooxygenase-1 and -2, the key enzymes of prostaglandin biosynthesis: in vitro assays

Popis výsledku v původním jazyce

Carvacrol is a phenolic monoterpene which is one of the most abundant constituents in essential oil of many aromatic plants such as oregano (Origanum vulgare L.), savory (Satureja thymbra L.), thyme (Thymus vulgaris L.), rosemary (Rosmarinus officinalisL.), fennel (Foeniculum vulgare L.) and black cumin (Nigella sativa L.). These species are widely used in traditional medicine against various microbial diseases and gastrointestinal and inflammatory disorders. Antimicrobial, antiangiogenic, antioxidative and analgesic activity of carvacrol was also confirmed by recent studies [1, 2]. Carvacrol is closely related to other phenolic monoterpenes as thymol or eugenol, which anti-inflammatory effects have been published [3]. The inhibition of cyclooxygenase-1 (COX-1) and ?2 (COX-2) enzymatic activities by carvacrol is reported here. The anti-inflammatory assay was based on inhibition of activity of COX-1 and ?2, which catalyzes prostaglandin biosynthesis from [14C] radioactive arachidonic a

Název v anglickém jazyce

Carvacrol as the inhibitor of cyclooxygenase-1 and -2, the key enzymes of prostaglandin biosynthesis: in vitro assays

Popis výsledku anglicky

Carvacrol is a phenolic monoterpene which is one of the most abundant constituents in essential oil of many aromatic plants such as oregano (Origanum vulgare L.), savory (Satureja thymbra L.), thyme (Thymus vulgaris L.), rosemary (Rosmarinus officinalisL.), fennel (Foeniculum vulgare L.) and black cumin (Nigella sativa L.). These species are widely used in traditional medicine against various microbial diseases and gastrointestinal and inflammatory disorders. Antimicrobial, antiangiogenic, antioxidative and analgesic activity of carvacrol was also confirmed by recent studies [1, 2]. Carvacrol is closely related to other phenolic monoterpenes as thymol or eugenol, which anti-inflammatory effects have been published [3]. The inhibition of cyclooxygenase-1 (COX-1) and ?2 (COX-2) enzymatic activities by carvacrol is reported here. The anti-inflammatory assay was based on inhibition of activity of COX-1 and ?2, which catalyzes prostaglandin biosynthesis from [14C] radioactive arachidonic a

Druh

D - Stať ve sborníku

CEP obor

GM - Potravinářství

OECD FORD obor

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Projekt

<a href="/cs/project/GA525%2F06%2F0864" target="_blank" >GA525/06/0864: Revize taxonomické distribuce isoflavonoidů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Planta Medica: 54th Congress on Medicinal Plant Research

ISBN

ISSN 0032-0943

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

1010-1010

Název nakladatele

Georg Thieme Verlag KG, Stuttgard

Místo vydání

Stuttgart, Germany

Místo konání akce

Helsinki, Finland

Datum konání akce

29. 9. 2006

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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