Antifungal Polyamides of Hydroxycinnamic Acids from Sunflower Bee Pollen

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916666" target="_blank" >RIV/60461373:22310/18:43916666 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/18:43916666 RIV/60461373:22340/18:43916666 RIV/60461373:22810/18:43916666

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.jafc.8b03976" target="_blank" >http://dx.doi.org/10.1021/acs.jafc.8b03976</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jafc.8b03976" target="_blank" >10.1021/acs.jafc.8b03976</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antifungal Polyamides of Hydroxycinnamic Acids from Sunflower Bee Pollen

Popis výsledku v původním jazyce

The aim of the bioassay-guided fractionation was the selection of the most potent group of compounds responsible for the protection of sunflower bee pollen grains. Synthesis of prospective antifungal polyamides of hydroxycinnamic acids was based on previous structural elucidation of ethanol soluble fraction by H-1,H-1-PFG-COSY, H-1,C-13-HSQC, FT-IR, FT-Raman, and LC-MS experiments. The main compounds found were tri-p-coumaroylspermidines accompanied by other HCAA of spermidine and putrescine. Several model HCAA derivatives were prepared to test their antifungal activity against widespread spoilage fungi (A. niger 42 CCM 8189, F. culmorum DMF 0103, and P. verrucosum DMF 0023). A. niger CCM 8189 and F. culmorum DMF 0103 exhibited higher resistance to the antifungal effects of hydroxycinnamic acid amides, whereas P. verrucosum DMF 0023 was the most sensitive strain. It has been discovered the effect of HCAA polarity on the role of secondary metabolites in the microbial protection of pollen grains. The combination of bioassay-guided fractionation, structural elucidation, selection of prospective compounds, and their synthesis to determine their antifungal properties could be considered as an original approach.

Název v anglickém jazyce

Antifungal Polyamides of Hydroxycinnamic Acids from Sunflower Bee Pollen

Popis výsledku anglicky

The aim of the bioassay-guided fractionation was the selection of the most potent group of compounds responsible for the protection of sunflower bee pollen grains. Synthesis of prospective antifungal polyamides of hydroxycinnamic acids was based on previous structural elucidation of ethanol soluble fraction by H-1,H-1-PFG-COSY, H-1,C-13-HSQC, FT-IR, FT-Raman, and LC-MS experiments. The main compounds found were tri-p-coumaroylspermidines accompanied by other HCAA of spermidine and putrescine. Several model HCAA derivatives were prepared to test their antifungal activity against widespread spoilage fungi (A. niger 42 CCM 8189, F. culmorum DMF 0103, and P. verrucosum DMF 0023). A. niger CCM 8189 and F. culmorum DMF 0103 exhibited higher resistance to the antifungal effects of hydroxycinnamic acid amides, whereas P. verrucosum DMF 0023 was the most sensitive strain. It has been discovered the effect of HCAA polarity on the role of secondary metabolites in the microbial protection of pollen grains. The combination of bioassay-guided fractionation, structural elucidation, selection of prospective compounds, and their synthesis to determine their antifungal properties could be considered as an original approach.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21101 - Food and beverages

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Agricultural and Food Chemistry

ISSN

0021-8561

e-ISSN

—

Svazek periodika

66

Číslo periodika v rámci svazku

42

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

11018-11026

Kód UT WoS článku

000448754600009

EID výsledku v databázi Scopus

2-s2.0-85055093412