Determination of major phytocannabinoids employing ultra-high performance liquid chromatography coupled to high resolution tandem mass spectrometry technique

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43901502" target="_blank" >RIV/60461373:22330/15:43901502 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of major phytocannabinoids employing ultra-high performance liquid chromatography coupled to high resolution tandem mass spectrometry technique

Popis výsledku v původním jazyce

In any case, effective analytical control of cannabinoids levels in respective plants and products is of a high concern. Currently, liquid chromatography separation coupled to mass spectrometric detection is a preferred technique used for cannabinoids analysis since it provides sufficiently low limits of quantification (LOQ) in a variety of matrices. One of the analytical challenges encountered in phytocannabinoids analysis is a very wide range (even several orders of magnitude) of concentrations at which they occur in analyzed samples. This makes quantification process rather difficult, specifically when HR mass analyzers with a relatively narrow dynamic range (TOF, Orbitrap) are employed for detection. Within this study concerned simultaneous analysis of 7 phytocannabinoids, we focused on overcoming this problem by various settings of Q-Orbitrap analyzer combining different MS experiments in order to ensure sufficient sensitivity for low-abundant analytes and prevent from detector sa

Název v anglickém jazyce

Determination of major phytocannabinoids employing ultra-high performance liquid chromatography coupled to high resolution tandem mass spectrometry technique

Popis výsledku anglicky

In any case, effective analytical control of cannabinoids levels in respective plants and products is of a high concern. Currently, liquid chromatography separation coupled to mass spectrometric detection is a preferred technique used for cannabinoids analysis since it provides sufficiently low limits of quantification (LOQ) in a variety of matrices. One of the analytical challenges encountered in phytocannabinoids analysis is a very wide range (even several orders of magnitude) of concentrations at which they occur in analyzed samples. This makes quantification process rather difficult, specifically when HR mass analyzers with a relatively narrow dynamic range (TOF, Orbitrap) are employed for detection. Within this study concerned simultaneous analysis of 7 phytocannabinoids, we focused on overcoming this problem by various settings of Q-Orbitrap analyzer combining different MS experiments in order to ensure sufficient sensitivity for low-abundant analytes and prevent from detector sa

Druh

O - Ostatní výsledky

CEP obor

GM - Potravinářství

OECD FORD obor

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Projekt

<a href="/cs/project/TA04010331" target="_blank" >TA04010331: Charakterizace a selekce C. sativa po potravinářské i nepotravinářské využití pomocí biotechnologických postupů a vysokokapacitních metod.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů