Voltammetric analysis of mephenoxalone drug in pharmaceutical and biological samples using novel screen-printed sensor with boron-doped diamond electrode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F23%3A00576141" target="_blank" >RIV/61388955:_____/23:00576141 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216275:25310/23:39920589 RIV/61989592:15310/23:73621797

Výsledek na webu

<a href="https://hdl.handle.net/11104/0345733" target="_blank" >https://hdl.handle.net/11104/0345733</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.snb.2023.134700" target="_blank" >10.1016/j.snb.2023.134700</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetric analysis of mephenoxalone drug in pharmaceutical and biological samples using novel screen-printed sensor with boron-doped diamond electrode

Popis výsledku v původním jazyce

A novel screen-printed sensor (SPE) with boron-doped diamond electrode (BDDE) for determination of a muscle relaxant and mild anxiolytic mephenoxalone (MNL) was developed. The sensor utilizes the electrochemical oxidation of MNL, which was firstly studied in aqueous solution using oxygen terminated BDDE. MNL provided an irreversible anodic signal at a potential of + 1380 mV (vs. Ag/AgCl/KCl sat.) over a wide pH range. Britton-Robinson buffer (pH 9) was selected as a suitable electrolyte and the square-wave voltammetric method (SWV) was developed. The low detection limit (55 nmol L–1), wide linear dynamic range (0.1–30 µmol L−1), and good recovery in the analysis of model and pharmaceutical samples (RSD < 1.77%) were attained. Subsequently, the new method was successfully transferred to SPE, which can find application in point-of-care testing. These sensors proved excellent sensitivity and reproducibility in the analysis of biological samples (RSD < 4.94%) without pretreatment and no need of electrolyte. Based on gas chromatography with mass spectrometry (GC-MS) analysis of preparative electrolysis products, a mechanism of the electrochemical oxidation of MNL was proposed, describing the oxidative cleavage of the alkoxybenzene ring. These results were supported with HOMO spatial distribution calculations and atomic charges calculations for arising radical cations, and with spectroelectrochemical measurements.

Název v anglickém jazyce

Voltammetric analysis of mephenoxalone drug in pharmaceutical and biological samples using novel screen-printed sensor with boron-doped diamond electrode

Popis výsledku anglicky

A novel screen-printed sensor (SPE) with boron-doped diamond electrode (BDDE) for determination of a muscle relaxant and mild anxiolytic mephenoxalone (MNL) was developed. The sensor utilizes the electrochemical oxidation of MNL, which was firstly studied in aqueous solution using oxygen terminated BDDE. MNL provided an irreversible anodic signal at a potential of + 1380 mV (vs. Ag/AgCl/KCl sat.) over a wide pH range. Britton-Robinson buffer (pH 9) was selected as a suitable electrolyte and the square-wave voltammetric method (SWV) was developed. The low detection limit (55 nmol L–1), wide linear dynamic range (0.1–30 µmol L−1), and good recovery in the analysis of model and pharmaceutical samples (RSD < 1.77%) were attained. Subsequently, the new method was successfully transferred to SPE, which can find application in point-of-care testing. These sensors proved excellent sensitivity and reproducibility in the analysis of biological samples (RSD < 4.94%) without pretreatment and no need of electrolyte. Based on gas chromatography with mass spectrometry (GC-MS) analysis of preparative electrolysis products, a mechanism of the electrochemical oxidation of MNL was proposed, describing the oxidative cleavage of the alkoxybenzene ring. These results were supported with HOMO spatial distribution calculations and atomic charges calculations for arising radical cations, and with spectroelectrochemical measurements.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

<a href="/cs/project/GA20-01589S" target="_blank" >GA20-01589S: Nové strategie pro zlepšení senzorových vlastností nových elektrodových materiálů prostřednictvím jejich předúpravy či modifikace povrchu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sensors and Actuators B - Chemical

ISSN

0925-4005

e-ISSN

0925-4005

Svazek periodika

397

Číslo periodika v rámci svazku

DEC 2023

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

134700

Kód UT WoS článku

001165280100001

EID výsledku v databázi Scopus

2-s2.0-85173127132