Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+ and Zn2+ ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00581912" target="_blank" >RIV/61389013:_____/24:00581912 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14160/24:00135402 RIV/00027162:_____/24:N0000008

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0268005X23012390?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0268005X23012390?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.foodhyd.2023.109693" target="_blank" >10.1016/j.foodhyd.2023.109693</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+ and Zn2+ ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics

Popis výsledku v původním jazyce

Alginate gels are outstanding biomaterials widely applicable in food and pharmaceutical industries. This contribution provides comprehensive insight into the design of advanced hybrid alginate/pectin co-networks double crosslinked by Ca2+/Zn2+ ions encapsulating self-emulsifying systems (SES). The tunable mucoadhesive properties, structural stability, integrity, dissolution profiles, and enhanced in-vivo bioavailability make the synthesized hybrid systems ideal vehicles for the delivery of lipophilic phytotherapeutics, allowing the long-term site-specific treatment of intestinal inflammation. This work also provides a thorough understanding of the structure-property relationships of alginate-pectin gels at the atomic resolution level. It was found out that SES molecules form well-distributed, phase-separated microparticles that interact with the polysaccharide matrix through a well-defined interface. The hybrid alginate-pectin gel is highly cross-linked, with both types of polysaccharides participating in the network formation. The observed surface interactions of SES droplets increase the intrinsic mobility of the network. The plasticizing effect can be regulated by the amount of pectin macromolecules, whose interaction with alginate chains enables a strengthening of the polysaccharide network. Overall, the domain-like architecture of hybrid alginate-pectin gels synthesized by external ionic gelation is revealed, the key structural motifs responsible for their properties are discovered, and the pathways allowing their regulation are identified. Biological in-vivo tests then confirmed positive effects of the synthesized systems in living organisms. The strategy presented thus offers a new perspective for the rational design of alginate-based materials for the microencapsulation of bioactive compounds for advanced orally administered delivery systems or controlled-release decontaminators applicable in the food and nutraceutical processing industries.

Název v anglickém jazyce

Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+ and Zn2+ ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics

Popis výsledku anglicky

Alginate gels are outstanding biomaterials widely applicable in food and pharmaceutical industries. This contribution provides comprehensive insight into the design of advanced hybrid alginate/pectin co-networks double crosslinked by Ca2+/Zn2+ ions encapsulating self-emulsifying systems (SES). The tunable mucoadhesive properties, structural stability, integrity, dissolution profiles, and enhanced in-vivo bioavailability make the synthesized hybrid systems ideal vehicles for the delivery of lipophilic phytotherapeutics, allowing the long-term site-specific treatment of intestinal inflammation. This work also provides a thorough understanding of the structure-property relationships of alginate-pectin gels at the atomic resolution level. It was found out that SES molecules form well-distributed, phase-separated microparticles that interact with the polysaccharide matrix through a well-defined interface. The hybrid alginate-pectin gel is highly cross-linked, with both types of polysaccharides participating in the network formation. The observed surface interactions of SES droplets increase the intrinsic mobility of the network. The plasticizing effect can be regulated by the amount of pectin macromolecules, whose interaction with alginate chains enables a strengthening of the polysaccharide network. Overall, the domain-like architecture of hybrid alginate-pectin gels synthesized by external ionic gelation is revealed, the key structural motifs responsible for their properties are discovered, and the pathways allowing their regulation are identified. Biological in-vivo tests then confirmed positive effects of the synthesized systems in living organisms. The strategy presented thus offers a new perspective for the rational design of alginate-based materials for the microencapsulation of bioactive compounds for advanced orally administered delivery systems or controlled-release decontaminators applicable in the food and nutraceutical processing industries.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA22-03187S" target="_blank" >GA22-03187S: Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spekterem biologické aktivity k terapii sliznic</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Food Hydrocolloids

ISSN

0268-005X

e-ISSN

1873-7137

Svazek periodika

150

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

109693

Kód UT WoS článku

001154019500001

EID výsledku v databázi Scopus

2-s2.0-85182024378