Antigen Cross-Presentation and Heat Shock Protein-Based Vaccines

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33162267" target="_blank" >RIV/61989592:15110/16:33162267 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs00005-015-0370-x" target="_blank" >http://link.springer.com/article/10.1007%2Fs00005-015-0370-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00005-015-0370-x" target="_blank" >10.1007/s00005-015-0370-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antigen Cross-Presentation and Heat Shock Protein-Based Vaccines

Popis výsledku v původním jazyce

Vaccines currently in the clinical use contain adjuvants stimulating preferably Th2 type of immune response associated with the production of specific antibodies, mostly of neutralizing isotypes. This kind of immune response is effective only against some types of pathogens and has limited effect against tumors and many viruses where parallel activation of antigen-specific humoral and cell-mediated immunity is required. One of the main objectives of the current vaccine research is the development of approaches leading to the induction of antigen-specific CD8? T cell response including cytotoxic T lymphocyte (CTL). Induction of antigen-specific CD8? T cell response to exogenously delivered antigen requires their cross-presentation by antigen presenting cells, especially dendritic cells. The cross-presentation principles seem to be crucial for effective activation of CTL. In this paper, we discuss some approaches to employing heat shock proteins for induction of antigen-specific CD8? T cells in the context of cross-presentation and cross-priming principles.

Název v anglickém jazyce

Antigen Cross-Presentation and Heat Shock Protein-Based Vaccines

Popis výsledku anglicky

Vaccines currently in the clinical use contain adjuvants stimulating preferably Th2 type of immune response associated with the production of specific antibodies, mostly of neutralizing isotypes. This kind of immune response is effective only against some types of pathogens and has limited effect against tumors and many viruses where parallel activation of antigen-specific humoral and cell-mediated immunity is required. One of the main objectives of the current vaccine research is the development of approaches leading to the induction of antigen-specific CD8? T cell response including cytotoxic T lymphocyte (CTL). Induction of antigen-specific CD8? T cell response to exogenously delivered antigen requires their cross-presentation by antigen presenting cells, especially dendritic cells. The cross-presentation principles seem to be crucial for effective activation of CTL. In this paper, we discuss some approaches to employing heat shock proteins for induction of antigen-specific CD8? T cells in the context of cross-presentation and cross-priming principles.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

<a href="/cs/project/EE2.3.20.0164" target="_blank" >EE2.3.20.0164: Rozvoj mezinárodního týmu excelence pro výzkum a cílenou léčbu hematologických a imunologických chorob</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archivum Immunologiae et Therapiae Experimentalis

ISSN

1661-4917

e-ISSN

—

Svazek periodika

64

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

18

Strana od-do

1-18

Kód UT WoS článku

000368536300001

EID výsledku v databázi Scopus

2-s2.0-84954389632