Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F14%3A00217718" target="_blank" >RIV/62156489:43210/14:00217718 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/14:43875120 RIV/62157124:16270/14:43872978 RIV/00216305:26220/14:PU112438

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1214021X13000094" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X13000094</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2013.01.002" target="_blank" >10.1016/j.jab.2013.01.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

Popis výsledku v původním jazyce

Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitoredboth enzymatic and non-enzymatic antioxidants -- glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enz

Název v anglickém jazyce

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

Popis výsledku anglicky

Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitoredboth enzymatic and non-enzymatic antioxidants -- glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enz

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of applied biomedicine

ISSN

1214-021X

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

14

Strana od-do

97-110

Kód UT WoS článku

334441900005

EID výsledku v databázi Scopus

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