Transforming growth factor beta 1 production during inflammatory response of mammary gland induced by peptidoglycan

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43914678" target="_blank" >RIV/62156489:43210/18:43914678 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2018/mnet_2018_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2018/mnet_2018_full.pdf</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Transforming growth factor beta 1 production during inflammatory response of mammary gland induced by peptidoglycan

Popis výsledku v původním jazyce

Intramammary infection promotes increase in production of two isoforms of transforming growth factor beta (TGF-β) which are TGF-β1 and TGF-β2. The aim of this study was to investigate the production of TGF-β1 during an inflammatory response of bovine mammary gland induced by peptidoglycan of S. aureus. The experiment was performed on 32 mammary glands of 8 healthy virgin crossbred heifers. Lavages of the mammary glands were analysed using sandwich ELISA technique. The results showed that stimulation with peptidoglycan led to a significant increase in the concentration of TGF-β1. We suggest that peptidoglycan of S. aureus stimulated immune cells to production of TGF-β1 at least in three days following stimulation of mammary glands. TGF-β1 is one of the most important cytokines in restoring the mammary gland within mastitis and stimulation with peptidoglycan helped us see the heifer&apos;s mammary gland immune response.

Název v anglickém jazyce

Transforming growth factor beta 1 production during inflammatory response of mammary gland induced by peptidoglycan

Popis výsledku anglicky

Intramammary infection promotes increase in production of two isoforms of transforming growth factor beta (TGF-β) which are TGF-β1 and TGF-β2. The aim of this study was to investigate the production of TGF-β1 during an inflammatory response of bovine mammary gland induced by peptidoglycan of S. aureus. The experiment was performed on 32 mammary glands of 8 healthy virgin crossbred heifers. Lavages of the mammary glands were analysed using sandwich ELISA technique. The results showed that stimulation with peptidoglycan led to a significant increase in the concentration of TGF-β1. We suggest that peptidoglycan of S. aureus stimulated immune cells to production of TGF-β1 at least in three days following stimulation of mammary glands. TGF-β1 is one of the most important cytokines in restoring the mammary gland within mastitis and stimulation with peptidoglycan helped us see the heifer&apos;s mammary gland immune response.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2018: Proceedings of International PhD Students Conference

ISBN

978-80-7509-597-8

ISSN

—

e-ISSN

neuvedeno

Počet stran výsledku

4

Strana od-do

366-369

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

7. 11. 2018

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000462205300068