Apoptotické faktory (Fas receptor, Fas ligand, FADD) v časném vývoji zubů hraboše mokřadního (Microtus agrestis)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F05%3A00000279" target="_blank" >RIV/62157124:16170/05:00000279 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/05:00022963

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Apoptosis-related factors (Fas receptor, Fas ligand, FADD) in early tooth development of the field vole (Microtus agrestis)

Popis výsledku v původním jazyce

Fas (CD95/APO-1) belongs to the TNF receptor (TNFR) family. Fas ligand binding followed by Fas-receptor oligomerisation leads to formation of a death-inducing signal complex starting with recruitment of the Fas-adapter protein (FADD). Components of thisinitiation complex (Fas, Fas-L, FADD) were correlated with apoptotic cells, detected by specific DNA fragmentation and morphological criteria.Apoptotic cells can by detected throughout the embryonic deveolpment of molar teeth. Restricted temporospatial distribution suggest several important roles for apoptosis in tooth morphogenesis. However, the mechanisms employed in dental apoptosis remain unclear.Frontal sections of the field vole at stage 13.5 - 15.5 of embryonic development were exploited to investigate and correlate location of Fas, Fas-ligand, FADD molecules and apoptosis in developing first molars by immunohistochemistry. During these stages the primary enamel knot appears and is gradually terminated by apoptosis. Initially, ap

Název v anglickém jazyce

Apoptosis-related factors (Fas receptor, Fas ligand, FADD) in early tooth development of the field vole (Microtus agrestis)

Popis výsledku anglicky

Fas (CD95/APO-1) belongs to the TNF receptor (TNFR) family. Fas ligand binding followed by Fas-receptor oligomerisation leads to formation of a death-inducing signal complex starting with recruitment of the Fas-adapter protein (FADD). Components of thisinitiation complex (Fas, Fas-L, FADD) were correlated with apoptotic cells, detected by specific DNA fragmentation and morphological criteria.Apoptotic cells can by detected throughout the embryonic deveolpment of molar teeth. Restricted temporospatial distribution suggest several important roles for apoptosis in tooth morphogenesis. However, the mechanisms employed in dental apoptosis remain unclear.Frontal sections of the field vole at stage 13.5 - 15.5 of embryonic development were exploited to investigate and correlate location of Fas, Fas-ligand, FADD molecules and apoptosis in developing first molars by immunohistochemistry. During these stages the primary enamel knot appears and is gradually terminated by apoptosis. Initially, ap

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Oral Biology

ISSN

0003-9969

e-ISSN

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Svazek periodika

50

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

165-169

Kód UT WoS článku

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EID výsledku v databázi Scopus

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