Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F15%3A00457459" target="_blank" >RIV/67985882:_____/15:00457459 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1364/OE.23.020132" target="_blank" >http://dx.doi.org/10.1364/OE.23.020132</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1364/OE.23.020132" target="_blank" >10.1364/OE.23.020132</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers

Popis výsledku v původním jazyce

A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA](n) multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 degrees C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Ourfindings underscore the importance of conducting drug release studies in physiologically relevant conditions

Název v anglickém jazyce

Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers

Popis výsledku anglicky

A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA](n) multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 degrees C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Ourfindings underscore the importance of conducting drug release studies in physiologically relevant conditions

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JA - Elektronika a optoelektronika, elektrotechnika

OECD FORD obor

—

Projekt

<a href="/cs/project/LH11038" target="_blank" >LH11038: Chemické a biochemické senzory založené na funkcionalizovaných mikro- a nanostrukturovaných optických vlnovodech</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Optics Express

ISSN

1094-4087

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

20132-20142

Kód UT WoS článku

000361035300151

EID výsledku v databázi Scopus

2-s2.0-84954473447