Role of silica nanoparticles in monitoring and prolonging release of drug-eluting polyelectrolyte coatings using long-period fiber grating platform
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F17%3A00484862" target="_blank" >RIV/67985882:_____/17:00484862 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.snb.2017.06.048" target="_blank" >http://dx.doi.org/10.1016/j.snb.2017.06.048</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.snb.2017.06.048" target="_blank" >10.1016/j.snb.2017.06.048</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Role of silica nanoparticles in monitoring and prolonging release of drug-eluting polyelectrolyte coatings using long-period fiber grating platform
Popis výsledku v původním jazyce
ilica nanoparticles (SNPs) were synergistically integrated with long-period grating (LPG) platform and the process of layer-by-layer (LbL) assembly to enable monitoring controlled release of drug-eluting polyelectrolyte coatings. The SNPs afforded a high surface area for increased drug loading as well as enhanced evanescent field overlap. In addition, the SNPs positioned within the LbL coatings acted as diffusion barrier layer, leading to prolonged release profile. SNPs with different sizes were respectively immobilized on the LPG using poly allylamine hydrochloride (PAH). In-situ monitoring of drug-eluting LbL coating [chitosan (CHI)/Poly arylic acid (PAA)/Gentamicin sulfate (GS)PAA](n), was carried out on LPG with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SNPs with 50 nm in diameter. LPG without the SNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer, indicating the significant ability of SNPs in enhancing the LPG sensitivity. Drug release measurement carried out on the LPG platform revealed an increased release time for LbL-SNP drug delivery system compared with that of LbL alone
Název v anglickém jazyce
Role of silica nanoparticles in monitoring and prolonging release of drug-eluting polyelectrolyte coatings using long-period fiber grating platform
Popis výsledku anglicky
ilica nanoparticles (SNPs) were synergistically integrated with long-period grating (LPG) platform and the process of layer-by-layer (LbL) assembly to enable monitoring controlled release of drug-eluting polyelectrolyte coatings. The SNPs afforded a high surface area for increased drug loading as well as enhanced evanescent field overlap. In addition, the SNPs positioned within the LbL coatings acted as diffusion barrier layer, leading to prolonged release profile. SNPs with different sizes were respectively immobilized on the LPG using poly allylamine hydrochloride (PAH). In-situ monitoring of drug-eluting LbL coating [chitosan (CHI)/Poly arylic acid (PAA)/Gentamicin sulfate (GS)PAA](n), was carried out on LPG with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SNPs with 50 nm in diameter. LPG without the SNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer, indicating the significant ability of SNPs in enhancing the LPG sensitivity. Drug release measurement carried out on the LPG platform revealed an increased release time for LbL-SNP drug delivery system compared with that of LbL alone
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
20201 - Electrical and electronic engineering
Návaznosti výsledku
Projekt
<a href="/cs/project/GBP205%2F12%2FG118" target="_blank" >GBP205/12/G118: Nanobiofotonika pro medicínu budoucnosti</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Sensors and Actuators B - Chemical
ISSN
0925-4005
e-ISSN
—
Svazek periodika
252
Číslo periodika v rámci svazku
November
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
9
Strana od-do
831-839
Kód UT WoS článku
000408277500098
EID výsledku v databázi Scopus
2-s2.0-85020908616