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Silica nanoparticle coated long-period grating for in situ monitoring of drug delivery thin films

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F17%3A00488294" target="_blank" >RIV/67985882:_____/17:00488294 - isvavai.cz</a>

  • Výsledek na webu

    <a href="http://dx.doi.org/10.1117/12.2252816" target="_blank" >http://dx.doi.org/10.1117/12.2252816</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1117/12.2252816" target="_blank" >10.1117/12.2252816</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Silica nanoparticle coated long-period grating for in situ monitoring of drug delivery thin films

  • Popis výsledku v původním jazyce

    Dielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin filmDielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin film

  • Název v anglickém jazyce

    Silica nanoparticle coated long-period grating for in situ monitoring of drug delivery thin films

  • Popis výsledku anglicky

    Dielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin filmDielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin film

Klasifikace

  • Druh

    D - Stať ve sborníku

  • CEP obor

  • OECD FORD obor

    10306 - Optics (including laser optics and quantum optics)

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/LH11038" target="_blank" >LH11038: Chemické a biochemické senzory založené na funkcionalizovaných mikro- a nanostrukturovaných optických vlnovodech</a><br>

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2017

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název statě ve sborníku

    OPTICAL FIBERS AND SENSORS FOR MEDICAL DIAGNOSTICS AND TREATMENT APPLICATIONS XVII

  • ISBN

    978-151060557-2

  • ISSN

    0277-786X

  • e-ISSN

    2410-9045

  • Počet stran výsledku

    16

  • Strana od-do

  • Název nakladatele

    SPIE

  • Místo vydání

    Bellingham

  • Místo konání akce

    San Francisco

  • Datum konání akce

    28. 1. 2017

  • Typ akce podle státní příslušnosti

    WRD - Celosvětová akce

  • Kód UT WoS článku

    000406420600007