Silica nanoparticle coated long-period grating for in situ monitoring of drug delivery thin films
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F17%3A00488294" target="_blank" >RIV/67985882:_____/17:00488294 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1117/12.2252816" target="_blank" >http://dx.doi.org/10.1117/12.2252816</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1117/12.2252816" target="_blank" >10.1117/12.2252816</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Silica nanoparticle coated long-period grating for in situ monitoring of drug delivery thin films
Popis výsledku v původním jazyce
Dielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin filmDielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin film
Název v anglickém jazyce
Silica nanoparticle coated long-period grating for in situ monitoring of drug delivery thin films
Popis výsledku anglicky
Dielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin filmDielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin film
Klasifikace
Druh
D - Stať ve sborníku
CEP obor
—
OECD FORD obor
10306 - Optics (including laser optics and quantum optics)
Návaznosti výsledku
Projekt
<a href="/cs/project/LH11038" target="_blank" >LH11038: Chemické a biochemické senzory založené na funkcionalizovaných mikro- a nanostrukturovaných optických vlnovodech</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název statě ve sborníku
OPTICAL FIBERS AND SENSORS FOR MEDICAL DIAGNOSTICS AND TREATMENT APPLICATIONS XVII
ISBN
978-151060557-2
ISSN
0277-786X
e-ISSN
2410-9045
Počet stran výsledku
16
Strana od-do
—
Název nakladatele
SPIE
Místo vydání
Bellingham
Místo konání akce
San Francisco
Datum konání akce
28. 1. 2017
Typ akce podle státní příslušnosti
WRD - Celosvětová akce
Kód UT WoS článku
000406420600007