In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F15%3A00457461" target="_blank" >RIV/67985882:_____/15:00457461 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1117/12.2191683" target="_blank" >http://dx.doi.org/10.1117/12.2191683</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1117/12.2191683" target="_blank" >10.1117/12.2191683</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions

Popis výsledku v původním jazyce

The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA](n) polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA] n and a measurement probe for GS release.We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA] n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a rangeof dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multil

Název v anglickém jazyce

In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions

Popis výsledku anglicky

The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA](n) polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA] n and a measurement probe for GS release.We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA] n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a rangeof dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multil

Druh

D - Stať ve sborníku

CEP obor

JA - Elektronika a optoelektronika, elektrotechnika

OECD FORD obor

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Projekt

<a href="/cs/project/LH11038" target="_blank" >LH11038: Chemické a biochemické senzory založené na funkcionalizovaných mikro- a nanostrukturovaných optických vlnovodech</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of SPIE - FIBER OPTIC SENSORS AND APPLICATIONS XII

ISBN

978-1-62841-596-4

ISSN

0277-786X

e-ISSN

—

Počet stran výsledku

9

Strana od-do

9480051-9480059

Název nakladatele

SPIE

Místo vydání

Washington

Místo konání akce

Baltimore

Datum konání akce

22. 4. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000357019100004