Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F08%3A00338213" target="_blank" >RIV/68378041:_____/08:00338213 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice
Popis výsledku v původním jazyce
The spontaneous mutant frequency for mixed spermatogenic cells prepared from Pol heterozygous mice was significantly greater than that of wild-type controls, but no significant effect was found among the somatic tissues tested. Results shown in the paperdemonstrate that normal Pol abundance is necessary for normal BER activity, which is critical in maintaining a low germline mutant frequency. Notably, spermatogenic cells respond differently than somatic cells to Pol haploinsufficiency.
Název v anglickém jazyce
Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice
Popis výsledku anglicky
The spontaneous mutant frequency for mixed spermatogenic cells prepared from Pol heterozygous mice was significantly greater than that of wild-type controls, but no significant effect was found among the somatic tissues tested. Results shown in the paperdemonstrate that normal Pol abundance is necessary for normal BER activity, which is critical in maintaining a low germline mutant frequency. Notably, spermatogenic cells respond differently than somatic cells to Pol haploinsufficiency.

Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Rok uplatnění
2008
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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