Analysis of Gene Expression Changes in A549 Cells Induced by Organic Compounds from Respirable Air Particles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F14%3A00221690" target="_blank" >RIV/68407700:21230/14:00221690 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/14:00435218 RIV/00027162:_____/14:#0001185

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mrfmmm.2014.10.002" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2014.10.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mrfmmm.2014.10.002" target="_blank" >10.1016/j.mrfmmm.2014.10.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of Gene Expression Changes in A549 Cells Induced by Organic Compounds from Respirable Air Particles

Popis výsledku v původním jazyce

A number of toxic effects of respirable ambient air particles (genotoxic effects, inflammation, oxidative damage) have been attributed to organic compounds bound onto the particle surface. In this study, we analyzed global gene expression changes causedby the extractable organic matters (EOMs) from respirable airborne particles <2.5 ?m (PM2.5), collected at 3 localities from heavily polluted areas of the Czech Republic and a control locality with low pollution levels, in human lung epithelial A549 cells. Although the sampled localities differed in both extent and sources of air pollution, EOMs did not induce substantially different gene expression profiles. The number of transcripts deregulated in A549 cells treated with the lowest EOM concentration (10 ?g/ml) ranged from 65 to 85 in 4 sampling localities compared to the number of transcripts deregulated after 30 ?g/ml and 60 ?g/ml of EOMs, which ranged from 90 to 109, and from 149 to 452, respectively. We found numerous commonly dere

Název v anglickém jazyce

Analysis of Gene Expression Changes in A549 Cells Induced by Organic Compounds from Respirable Air Particles

Popis výsledku anglicky

A number of toxic effects of respirable ambient air particles (genotoxic effects, inflammation, oxidative damage) have been attributed to organic compounds bound onto the particle surface. In this study, we analyzed global gene expression changes causedby the extractable organic matters (EOMs) from respirable airborne particles <2.5 ?m (PM2.5), collected at 3 localities from heavily polluted areas of the Czech Republic and a control locality with low pollution levels, in human lung epithelial A549 cells. Although the sampled localities differed in both extent and sources of air pollution, EOMs did not induce substantially different gene expression profiles. The number of transcripts deregulated in A549 cells treated with the lowest EOM concentration (10 ?g/ml) ranged from 65 to 85 in 4 sampling localities compared to the number of transcripts deregulated after 30 ?g/ml and 60 ?g/ml of EOMs, which ranged from 90 to 109, and from 149 to 452, respectively. We found numerous commonly dere

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JC - Počítačový hardware a software

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

ISSN

0027-5107

e-ISSN

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Svazek periodika

770

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

94-105

Kód UT WoS článku

000345647400012

EID výsledku v databázi Scopus

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