Mapping Short Reads to a Genomic Sequence with Circular Structure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21240%2F12%3A00188306" target="_blank" >RIV/68407700:21240/12:00188306 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.igi-global.com/article/international-journal-systems-biology-biomedical/63044" target="_blank" >http://www.igi-global.com/article/international-journal-systems-biology-biomedical/63044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4018/ijsbbt.2012010103" target="_blank" >10.4018/ijsbbt.2012010103</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mapping Short Reads to a Genomic Sequence with Circular Structure

Popis výsledku v původním jazyce

Constant advances in DNA sequencing technologies are turning whole-genome sequencing into a routine procedure, resulting in massive amounts of data that need to be processed. Tens of gigabytes of data, in the form of short sequences (reads), need to be mapped back onto reference sequences, a few gigabases long. A first generation of short-read alignment algorithms successfully employed hash tables, and the current second generation uses the Burrows-Wheeler transform, further improving speed and memory footprint. These next-generation sequencing technologies allow researchers to characterise a bacterial genome, during a single experiment, at a moderate cost. In this article, as most of the bacterial chromosomes contain a circular DNA molecule, the authors present a new simple, yet efficient, sensitive and accurate algorithm, specifically designed for mapping millions of short reads to a genomic sequence with circular structure.

Název v anglickém jazyce

Mapping Short Reads to a Genomic Sequence with Circular Structure

Popis výsledku anglicky

Constant advances in DNA sequencing technologies are turning whole-genome sequencing into a routine procedure, resulting in massive amounts of data that need to be processed. Tens of gigabytes of data, in the form of short sequences (reads), need to be mapped back onto reference sequences, a few gigabases long. A first generation of short-read alignment algorithms successfully employed hash tables, and the current second generation uses the Burrows-Wheeler transform, further improving speed and memory footprint. These next-generation sequencing technologies allow researchers to characterise a bacterial genome, during a single experiment, at a moderate cost. In this article, as most of the bacterial chromosomes contain a circular DNA molecule, the authors present a new simple, yet efficient, sensitive and accurate algorithm, specifically designed for mapping millions of short reads to a genomic sequence with circular structure.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

IN - Informatika

OECD FORD obor

—

Projekt

<a href="/cs/project/GA201%2F09%2F0807" target="_blank" >GA201/09/0807: Analýza a zpracování řetězců a stromů</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Systems Biology and Biomedical Technologies

ISSN

2160-9586

e-ISSN

—

Svazek periodika

2012

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

26-34

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—